Description : Trikala (Greek: Τρίκαλα) is a city in northwestern Thessaly, Greece, and the capital of the Trikala regional unit. The city straddles the Lithaios river, which is a tributary of Pineios. According to the Greek National Statistical Service, Trikala is populated by 81,355 inhabitants (2011), while in total the Trikala regional unit is populated by 131,085 inhabitants (2011). The region of Trikala has been inhabited since prehistoric times. The first indications of permanent settlement have been uncovered in the cave of Theopetra, and date back to approx. 49,000 BC. Neolithic settlements dating back to 6,000 BC have been uncovered in Megalo Kefalovriso and other locations. The city of Trikala is built on the ancient city of Trikka or Trikke, which was founded around the 3rd millennium BC and took its name from the nymph Trikke, daughter of Peneus, or according to others, daughter of the river god Asopus. The ancient city was built at a defensive location in between the local hill and the river Lithaios. The city became an important center in antiquity and it was considered to be the birthplace and main residence of the healing god Asclepius. The city exhibited one of the most important and ancient of Asclepius' healing temples, called asclepieia. The city is mentioned in Homer's Iliad as having participated in the Trojan War with thirty ships under Asclepius' sons Machaon and Podalirius. In the Mycenean period, the city was the capital of a kingdom, and later it constituted the main center of the Thessalian region of Estaiotis, which occupied roughly the territory of the modern Trikala Prefecture. In historical times, the city of Trikke and the surrounding area experienced prosperity. It fell to the Achaemenid Persians in 480 BC, while ten years later it joined the Thessalian monetary union. In 352 BC it was united with the Macedonia of Philip II. The city became a location of hard battles between Macedonia and Rome. While Philip V of Macedon and his son Perseus tried to keep the city, after 168 BC it fell to the Roman Republic. Middle Ages While the area was considered to be firmly under the rule of the Byzantine Empire, it was invaded nevertheless by a succession of raiders and nomadic tribes. Some of these tribes that raided the area include: Goths (396), Huns (447), Slavs (577), Bulgarians (986-1000), Normans (1082/3), Catalans (1309–1311). The current name of Trikala first appears in the 11th-century Strategikon of Kekaumenos, where "Trikalitan Vlachs" are mentioned, and then in the early 12th-century Alexiad of Anna Komnene. Later in the century, the Arab traveller and geographer al-Idrisi recorded the town as "an important agrarian center with abundant vineyards and gardens" (T.E. Gregory). After the dissolution of the Byzantine state by the Fourth Crusade in 1204, Trikala does not appear to have fallen into Frankish hands, but became part of the Despotate of Epirus. Epirote rule lasted until 1259, when the town was taken without resistance by the Empire of Nicaea (after 1261 the renewed Byzantine Empire) following the Battle of Pelagonia. In the early 14th century the town was the capital of a semi-independent domain under the sebastokrator Stephen Gabrielopoulos, which extended across much of western Thessaly and Macedonia. After his death in 1332/3 the city, along with most of Gabrielopoulos' lands, was seized by the Epirote ruler John II Orsini, but he was in turn expelled and the area incorporated into the Byzantine Empire by Andronikos III Palaiologos. In 1348, Thessaly was conquered by Stephen Dushan and incorporated into the newly established Serbian Empire. The Serbian general Preljub was made the region's governor, and established himself at Trikala. In 1359, Dushan's half-brother Symeon Uroš established his court at Trikala, and in 1366/7 he founded the Meteora monasteries nearby. Symeon was succeeded by his son John Uroš, and he in turn by the local magnates Alexios Angelos Philanthropenos and Manuel Angelos Philanthropenos, who ruled until the Ottoman conquest of Thessaly in 1393/4.
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